Chemical and Pharmaceutical Bulletin p. 3834 - 3837 (1982)
Update date:2022-08-16
Topics:
Tada
Takahashi
Kawazoe
It was evidenced that quinoline was metabolized to quinoline 1-oxide catalyzed by cytochrome P-450-linked mixed function monooxygenase system and to 5,6-trans-dihydroxy-5,6-dihydroquinoline by cytochrome P-448-linked one. The third metabolite, 3-hydroxyquinoline, may be produced in another course of metabolism, which might be connected with genotoxicity of quinoline, as previously discussed.
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