Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases p. 2613 - 2630 (1983)
Update date:2022-08-10
Topics:
Bhattacharyya, Sudhindra N.
Mandal, Parikshit C.
Radiation sensitization of uracil (Ura) by CuII ions has been investigated using cobalt-60 γ-rays.In N2O-saturated solution, when no additive is present, the base degradation yield, G(-Ura), is only ca. 3.3, but when CuII ions are added in either a free or complexed state to the solution before irradiation, G(-Ura) is found to increase to ca. 5.1.The enhanced degradation of the base is derived from the oxidized transient, e.g.UraOH+, although reduction of CuII to CuI has been ascribed to all the primary adducts, e.g.UraH, UraOH and Ura-.Glycol and isobarbituric acid constitute the major products of radiolysis, which are derived from the oxidized UraOH+ species.Hydroxydihydrouracil and its dimer have also been detected in significant yields when the radiolysis is carried out at comparitively high absorbed doses.The formation of these products has been ascribed to a secondary reaction between UraOH and CuI which proceeds through the intermediate formation of a Cu-C bond.
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