Efficient synthesis of (S)-4(5)-[1-(2,3-dimethylphenyl) ethyl]imidazole tartrate, the potent α2 adrenoceptor agonist dexmedetomidine

Article abstract of DOI:10.1080/00397919608003527

(S,R)-4(5)-[1-(2,3-dimethylphenyl)ethyl]imidazole 5 is prepared in 41% yield, by a new reliable method from readily available starting materials. The separation of the enantiomers proceeds through the selective crystallisation of the (+)-tartrate of the (S) enantiomer 6 in the presence of the (R) enantiomer free base.

Full text of DOI:10.1080/00397919608003527

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Synthetic Communications: An
International Journal for Rapid
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Organic Chemistry
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Efficient Synthesis of (S)-4(5)-
[1-(2,3-Dimethylphenyl)
ethyl]imidazole tartrate,
the Potent α Adrenoceptor
2
Agonist Dexmedetomidine
a
a
Alex A. Cordi , Thierry Persigand & Jean-Pierre
b
Lecouvé
a
Institut de Recherches Servier, 11 rue des
Moulineaux, 92150, Suresnes, France
b
ORIL, 13 rue Auguste Desgenetais, BP 17, 76210,
Bolbec, France
Published online: 15 Aug 2006.
To cite this article: Alex A. Cordi , Thierry Persigand & Jean-Pierre Lecouvé (1996):
Efficient Synthesis of (S)-4(5)-[1-(2,3-Dimethylphenyl) ethyl]imidazole tartrate, the
Potent α Adrenoceptor Agonist Dexmedetomidine, Synthetic Communications: An
2
International Journal for Rapid Communication of Synthetic Organic Chemistry, 26:8,
1585-1593
To link to this article: http://dx.doi.org/10.1080/00397919608003527
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