Remarkable effects of donor esters on the α-chymotrypsin-catalyzed couplings of inherently poor amino acid substrates

DOI: 10.1016/S0040-4039(97)10798-5

Source and publish data:

Tetrahedron Letters p. 997 - 1000 (1998)

Update date:2022-08-12

Topics:

Authors:

Miyazawa, Toshifumi

Tanaka, Kayoko

Ensatsu, Eiichi

Yanagihara, Ryoji

Yamada, Takashi

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Article abstract of DOI:10.1016/S0040-4039(97)10798-5

The extremely low efficiency during the α-chymotrypsin-catalyzed coupling of an inherently poor amino acid substrate, e.g., alanine, using the methyl ester as an acyl donor was significantly improved using esters such as the 2,2,2-trifluoroethyl or carbamoylmethyl ester. The ameliorating effect of the latter ester was especially significant.

Full text of DOI:10.1016/S0040-4039(97)10798-5

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