Enantioselective 1,4-Addition of Aliphatic Grignard Reagents to Enones Catalyzed by Readily Available Copper(I) Thiolates Derived from TADDOL

Article abstract of DOI:10.1002/hlca.19970800819

Two simple thiols derived from the parent TADDOL, α,α,α + ′,α + ′-tetraphenyl-2,2-dimethyl-1,3-dioxolan-4,5-dimethanol, are used to prepare Cu¹ complexes C and D to catalyze (0.05 equiv.) 1,4-additions of Grignardreagents RMgCl to cyclic enones