Catalyzed acyl halide-aldehyde cyclocondensations. New insights into the design of catalytic cross aldol reactions

Article abstract of DOI:10.1016/S0040-4039(99)01308-8

Substoichiometric quantities (2.5-20 mol%) of Al(SbF₆)₃ catalyze the di(isopropyl)ethylamine-mediated cyclocondensation of various acyl halides and enolizable aldehydes to afford β-lactones in good yields (58-93%). These reactions ar