Bioorganic and Medicinal Chemistry Letters p. 1511 - 1516 (1996)
Update date:2022-08-17
Topics:
Naisbitt, Dean J.
Neill, Paul M.
Pirmohamed, Munir
Park, B. Kevin
Sulphamethoxazole hydroxylamine (SMX-NHOH) and nitroso sulphamethoxazole (SMX-NO) were prepared by a modified literature procedure. SMX-NO produced a complex set of unstable intermediates with sulphur nucleophiles, but did not react with amino containing compounds. No reactions were observed between sulphamethoxazole (SMX) / SMX-NHOH and the nucleophiles used in this study. Thus antigens formed from N-oxidation of SMX are likely to be unstable in vivo.
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