Synthesis of Carbon-11-, Fluorine-18-, and Iodine-125-Labeled GABAA-Gated Chloride Ion Channel Blockers: Substituted 5-tert-Butyl-2-phenyl-1,3-dithianes and -dithiane Oxides

Article abstract of DOI:10.1021/jm00014a018

A series of substituted 5-tert-butyl-2-phenyl-1,3-dithianes and 5-tert-butyl-2-phenyl-1,1,3,3-tetraoxo-1,3-dithianes was synthesized as ligands for the GABA_A receptor complex-associated neuronal chloride ion channels.The in vitro binding affini