A stereoselective synthesis of medium-sized cyclic ethers by the intramolecular cyclization of linear hydroxyalkyl-propargylic alcohols assisted by Co2(CO)8

Article abstract of DOI:10.1016/0040-4039(95)00555-Q

A highly efficient, mild and general cyclization reaction of hydroxy exo-(propargyl)Co₂(CO)₆ cations leading to medium-sized (6 to 9 membered) cyclic ethers is described. The reaction is highly stereoselective when defined stereocenters are encountered in the linear precursor, providing a way to obtain fused cyclic ethers in their enantiomeric forms.