Topical Nonsteroidal Antipsoriatic Agents. 2. 2,3-(Alkylidenedioxy)naphthalene Analogues of Lonapalene

DOI: 10.1021/jm00119a013

Source and publish data:

Journal of Medicinal Chemistry p. 2132 - 2136 (1988)

Update date:2022-08-11

Topics:

Authors:

Venuti, Michael C.

Loe, Brad E.

Jones, Gordon H.

Young, John M.

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Article abstract of DOI:10.1021/jm00119a013

A series of 2,3-(alkylidenedioxy)naphthalene analogues (5a-p) of lonapalene (RS-43179,1), a 5-lipoxygenase inhibitor currently under clinical investigation for the treatment of psoriasis, has been prepared and evaluated for topical inhibitory activity aga

Full text of DOI:10.1021/jm00119a013

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