Synthesis and biological evaluation of (±)-Z-huperzine A

DOI: 10.1016/S0040-4039(00)97013-8

Source and publish data:

Tetrahedron Letters p. 6159 - 6162 (1990)

Update date:2022-08-29

Topics:

Authors:

Kozikowski, Alan P.

Yamada, Fumio

Tang Tang

Hanin, Israel

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Article abstract of DOI:10.1016/S0040-4039(00)97013-8

The synthesis of (±)-Z-huperzine A has been accomplished and the ability of this agent to inhibit acetylcholinesterase has been measured. The compound has an IC₅₀ of 6 × 10^-6 M, which is comparable to that of huperzine B.

Full text of DOI:10.1016/S0040-4039(00)97013-8

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