ACS Medicinal Chemistry Letters p. 443 - 448 (2017)
Update date:2022-07-29
Topics:
Chen, Jichao
Wang, Ruifan
Wang, Tianyu
Ding, Qilong
Khalil, Aliahmad
Xu, Shengtao
Lin, Aijun
Yao, Hequan
Xie, Weijia
Zhu, Zheying
Xu, Jinyi
A series of novel β-elemene dimer derivatives were synthesized and evaluated for their antioxidant activities. The results indicated that most of the target compounds showed more potent cytoprotective effects than positive control vitamin E. In particular, dimer D5 exhibited the strongest antioxidant activity, which was significantly superior to the active compound D1 obtained in our previous study. Besides, D5 did not produce obvious cytotoxicity in normal human umbilical vein endothelial cells (HUVECs) and increased the viability of HUVECs injured by H2O2 in a concentration-dependent manner. Further studies suggested that the cytoprotective action of D5 might be mediated, at least in part, by increasing the intracellular superoxide dismutase activity and nitric oxide secretion as well as decreasing the intracellular malonyldialdehyde content and lactate dehydrogenase release. Furthermore, D5 observably inhibited ROS generation and prevented H2O2-induced apoptosis in HUVECs possibly via inhibiting the activation of the MAPK signaling pathway.
View MoreMelone Pharmaceutical Co., ltd
Contact:+86-411 82593920, 82593631
Address:No 232, JInma Roda, Development Zone, Dalian, China
Changzhou Jiana Chemical Co.,Ltd
website:http://www.jianachem.com
Contact:86-0519-88731808
Address:Zhenglu Town Wujin City, Jiangsu Province
website:http://www.fwdchem.com
Contact:86-21-54450828
Address:Room 802,Lotus Tower ,159 Tianzhou Road,Xuhui District,Shanghai
Shanghai better-in Medical Technology Co.,LTD.
Contact:+86-21-38921049
Address:Lane 720 zhangjianggaoke cailun road, Pudong, Shanghai, room 513
Contact:025-86793338
Address:nanjing jiangsu
Doi:10.1135/cccc19970800
(1997)Doi:10.1021/ja01584a041
(1956)Doi:10.1021/ol901305q
(2009)Doi:10.1248/cpb.36.2090
(1988)Doi:10.1016/j.poly.2018.12.007
(2019)Doi:10.1039/c39920000411
(1992)