Non-deprotonative primary and secondary amination of (hetero)arylmetals

Article abstract of DOI:10.1021/jacs.6b12712

Herein we disclose a novel method for the facile transfer of primary (-NH₂) and secondary amino groups (-NHR) to heteroaryl-as well as arylcuprates at low temperature without the need for precious metal catalysts, ligands, excess reagents, protecting and/or Erecting groups. This one-pot transformation allows unprecedented functional group tolerance and it is wellsuited for the amination of electron-rich, electron-deficient as well as structurally complex (hetero)arylmetals. In some of the cases, only catalytic amounts of a copper (l) salt is required.