Switching diastereoselectivity in proline-catalyzed aldol reactions

DOI: 10.1021/jo3020352

Source and publish data:

Journal of Organic Chemistry p. 10375 - 10381 (2012)

Update date:2022-08-16

Topics:

Authors:

Martinez-Castaneda, Angel

Rodriguez-Solla, Humberto

Concellon, Carmen

Del Amo, Vicente

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Article abstract of DOI:10.1021/jo3020352

The choice of the anion of an achiral TBD-derived guanidinium salt, used as cocatalyst for proline, allows reacting cycloketones with aromatic aldehydes and preparing either anti- or syn-aldol adducts with very high enantioselectivity. As a proof of princ

Full text of DOI:10.1021/jo3020352

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