Tetrahedron Asymmetry p. 2163 - 2172 (1993)
Update date:2022-08-11
Topics:
Zwaagstra
Meetsma
Feringa
A new synthetic route to (2S,5S)-dimethylpyrrolidine 1, which can also be applied to the synthesis of the (2R,5R)-enantiomer, has been developed. The C2-symmetric pyrrolidine can be obtained enantiomerically pure (e.e. ≥ 97%) in 15% overall yield starting from a mixture of isomers of 2,5-hexanediol, via a short reaction sequence using (S)-α-methylbenzylamine as a chiral auxiliary. The crystal and molecular structure of (S)-2'-phenyl-N-ethyl-(2S,5S)-dimethylpyrrolidine picrate 5, showing an antiparallel stacking of the picrate units, is also reported.
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(2014)Doi:10.1016/j.jallcom.2012.03.119
(2012)Doi:10.1007/BF00954462
(1983)Doi:10.1039/jr9530003261
(1953)Doi:10.1007/s00706-016-1829-0
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