Synlett p. 2866 - 2869 (2015)
Update date:2022-08-05
Topics:
Hu, Ting
Yan, Hao
Liu, Xingxing
Wu, Chaoyang
Fan, Yuxing
Huang, Jing
Huang, Guosheng
A nonmetal-catalyzed process for the synthesis of polysubstituted oxazoles from inexpensive and readily available α-amino acids and methyl ketones is established. This reaction is proposed to achieve oxidative cleavage of C(sp3)-H bonds, followed by decarboxylation and annulation. The mild reaction conditions employed in both cases enable the tolerance of a wide range of functional groups as well as high reaction efficiency.
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