Kinetics of solvolysis of 2-chloroquinoxaline

Article abstract of DOI:10.1002/kin.550260403

Pseudo-first-order rate constants and activation parameters have been measured for the solvolysis of 2-chloroquinoxaline in various aquo-organic mixtures using methanol, ethanol, and isopropanol as the organic solvent. Excellent linear correlations are found between lnk and the mol fraction of cosolvent and In[H₂O]. The medium effect on the rates of solvolysis is assessed by Grunwald-Winstein's mY correlationship. the estimated values of m (0.55-0.72) and the entropy of activation (148-212 J deg^-1 mol^-1) for the reactions are well in the range for a bimolecular aromatic substitution reactions.