ASYMMETRIC REDUCTION OF OXIME ETHERS. DISTINCTION OF ANTI AND SYN ISOMERS LEADING TO ENANTIOMERIC AMINES.

Article abstract of DOI:10.1016/S0040-4039(00)80059-3

Anti and syn ketoxime ethers were reduced with a chiral reducing agent prepared from (-)-norephedrine and 2 eq of BH3 to give S and R amines respectively in up to 92percentee.The preferred absolute configuration of the amine was dependent on the geometry of the oxime ether.