OXIDATIVE DECARBOXYLATION OF CYCLIC AMINO ACIDS AND DEHYDROGENATION OF CYCLIC SECONDARY AMINES WITH IODOSOBENZENE

Article abstract of DOI:10.1016/S0040-4039(00)88474-9

Cyclic amino acids L-proline, pipecolinic acid and L-2-pyrrolidinone-5-carboxylic acid undergo oxidative decarboxylation with iodosobenzene in various solvents (including water) to yield the lactam and imide in the latter case.The reaction proceeds via initial imine formation.