Tetrahedron Letters p. 2535 - 2538 (1985)
Update date:2022-08-11
Topics:
Elliott, John D.
Steele, John
Johnson, William S.
TiCl4 catalyzes the essentially quantitative coupling of chiral acetals 1 with 1-t-butoxy-1-t-butyldimethylsilyloxyethene 2 to generate β-alkoxycarboxylates in wich the new asymmetric center is formed with excellent diastereoselection. β-Hydrocarboxylic acids of high ee result from removal of the chiral auxiliary.The procedure has been appllied to the synthesis of R-(+)-α-lipoic acid 10.
View More
Contact:+86-20-89089654/ 89089744
Address:Poly World Trade Center C Tower 12 Floor 1211 Room No. 1000 Xingangdong Road Haizhu District Guangzhou 510305 Guangdong province China
Zhangjiagang Golden Reach Fine Chemical Co.,LTD.
Contact:+86-512-6585 6968
Address:Changfu Road， Dongsha Chemical Industry Park, Zhangjiagang City, Jiangsu Province, China
Beijing Green Guardee Technology CO,.LTD
Contact:+86-10-69706062
Address:F2 BLdj,5 No.37 Chaoqian Road
Nanjing Hemings New Material Tech Co.,Ltd.
Contact:+86-25-86606739
Address:NO.186 Jiangdong Mid Road,Nanjing China
RongCheng K&S Chemical Co.,Ltd
Contact:0631-7336369
Address:rongcheng ,shandong province china
Doi:10.1080/00397910701578578
(2007)Doi:10.1021/jacs.5b09158
(2015)Doi:10.1124/mol.115.098012
(2015)Doi:10.1016/j.tet.2017.03.014
(2017)Doi:10.1021/jo048736s
(2004)Doi:10.1021/ol050660e
(2005)
