The Chemistry of N-Substituted Benzotriazoles; Part 11. The preparation of Tertiary Amines Containing Tertiary-Alkyl Groups from Ketones, Secondary Amines, and Organometallic Reagents

Article abstract of DOI:10.1055/s-1989-27156

The preparation of important pharmaceutically active highly branched tertiary amines by the reaction of Grignard reagents with adducts of cyclic ketones, benzotriazole (or pyrazole) and secondary amines is far superior to previously available routes.