An efficient preparation of protected ribonucleosides for phosphoramidite RNA synthesis

Article abstract of DOI:10.1016/S0040-4039(02)00181-8

An efficient synthesis of protected ribonucleosides useful for phosphoramidite RNA synthesis is described. Di-t-butylsilylene group was employed for simultaneous protection of 3′- and 5′-hydroxyl functions of nucleoside. Subsequent silylation of free 2′-O