Alkylation of 2-acetylpyrrole and 1-alkyl-2-acetylpyrroles under solid/liquid phase-transfer conditions

Article abstract of DOI:10.1080/00397919108016783

The alkylation of 2-acetylpyrrole with alkyl iodides in the benzene/solid KOH system in the presence of 18-crown-6 at room temperature gives the corresponding 1-alkyl derivatives in high yields. The phase-transfer catalysed alkylation of 1-alkyl-2-acetylpyrroles without solvent leads to side-chain di-C-alkylated products, i.e. ketones of the (1-alkyl-2-pyrrolyl)COCHR₂ type in satisfactory yields.

Full text of DOI:10.1080/00397919108016783

Synthetic Communications
ISSN: 0039-7911 (Print) 1532-2432 (Online) Journal homepage: http://www.tandfonline.com/loi/lsyc20
Alkylation of 2-Acetylpyrrole and 1 -alkyl-2-
Acetylpyrroles Under Solid/Liquid Phase-Transfer
Conditions
Yu. Goldberg , E. [Abar]bele & M. Shymanska
To cite this article: Yu. Goldberg , E. [Abar]bele & M. Shymanska (1991) Alkylation of 2-
Acetylpyrrole and 1 -alkyl-2-Acetylpyrroles Under Solid/Liquid Phase-Transfer Conditions,
Synthetic Communications, 21:4, 557-562, DOI: 10.1080/00397919108016783
To link to this article: http://dx.doi.org/10.1080/00397919108016783
Published online: 23 Sep 2006.
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Date: 14 September 2015, At: 06:04