
Journal of the Chemical Society. Perkin transactions I p. 1765 - 1767 (1984)
Update date:2022-08-18
Topics:
Bardshiri, Esfandiar
Simpson, Thomas J.
Scott, A. Ian
Shishido, Kozo
Full details of a high yielding synthesis of mevalonic acid lactone (1) which is of particular value in the preparation of 3- and/or 3'-labelled compounds are described.The key step, conversion of 3-hydroxy-3-methylpentane-1,5-dioic acid (3) into 3-hydroxy-3-methylpentane-1,5-dioic anhydride (4) using acetic anhydride, has been fully investigated, and an additional method using acetyl chloride and triethylamine is described.
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