Heterocycles p. 1967 - 1978 (1997)
Update date:2022-08-16
Topics:
Vanden Eynde, Jean Jacques
Audiart, Nancy
Canonne, Vale?rie
Michel, Sophie
Van Haverbeke, Yves
Oliver Kappe
A series of 4-substituted ethyl 2-methoxy-6-methyl-1,4-dihydropyrimidine-5-carboxylates has been synthesized and was successfully aromatized to the corresponding pyrimidines with various oxidizing reagents. O-Demethylation of such pyrimidines provides a simple route to pyrimidinone derivatives which are otherwise difficult to obtain.
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Doi:10.1039/c1gc15606c
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(2015)
