Sodium percarbonate: A multifunctional reagent for the preparation of optically active 4-hydroxy-Δ2- isoxazolines

Article abstract of DOI:10.1016/S0040-4039(97)01597-9

In this letter we report a general method for the preparation of optically active 4-hydroxy-Δ²-isoxazolines. This one-pot method employs sodium percarbonate for nitrile oxide generation, oxidation of the intermediate boronic ester substituted Δ²-isoxazoline, and cleavage of the chiral auxiliary from the final product.