Synthesis of erythronolide A via direct macrolactonization of a conformationally controlled seco-acid with the Yamaguchi reagent in the presence of dimethylaminopyridine

DOI: 10.1248/cpb.40.2540

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2540 - 2542 (1992)

Update date:2022-08-11

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Authors:

Sakurai Sakurai

Hikota Hikota

Horita Horita

Yonemitsu

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Article abstract of DOI:10.1248/cpb.40.2540

Direct macrolactonization of 3,5-O-(3,4-dimethoxybenzylidene)-9,11-O-(2,4,6-trimethylbenzylidene)-( 9S)-9-dihydroerythronolide A seco-acid (3) with several reagents was examined under various conditions, and the Yamaguchi reagent (8) was found to be the m

Full text of DOI:10.1248/cpb.40.2540

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Product name:3,5-O-(3,4-dimethoxybenzylidene)-9,11-O-(2,4,6-trimethylbenzylidene)-(9S)-9-dihydroerythronolide A

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