6-deoxycarbovir: A xanthine oxidase activated prodrug of carbovir

Article abstract of DOI:10.1080/15257779508014651

(-)-(cis)-4-(2-Amino-9H-purin-9-yl)-2-cyclopentenyl carbinol (6-deoxycarbovir) was prepared in order to evaluate prodrug approaches to increased bioavailability of the anti-HIV agent, (-)-carbovir. Incubation experiments demonstrated that 6-deoxycarbovir was rapidly converted to (-)-carbovir by the enzyme, xanthine oxidase. Since xanthine oxidase activity is present in both the intestine and liver, a high first pass conversion to carbovir would be expected in vivo.

Full text of DOI:10.1080/15257779508014651

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6-Deoxycarbovir: A Xanthine Oxidase
Activated Prodrug of Carbovir
a
a
a
Robert Vince , Jay Brownell & Scott A. Beers
a
Department of Medicinal Chemistry , College of Pharmacy
08 Harvard St. S.E. University of Minnesota Minneapolis , MN,
5455-0343
3
5
Published online: 24 Sep 2006.
To cite this article: Robert Vince , Jay Brownell & Scott A. Beers (1995) 6-Deoxycarbovir: A
Xanthine Oxidase Activated Prodrug of Carbovir, Nucleosides and Nucleotides, 14:1-2, 39-44, DOI:
10.1080/15257779508014651
To link to this article: http://dx.doi.org/10.1080/15257779508014651
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