Pyrrolizidine alkaloids. A concise entry to (-)-pyrrolam A

Article abstract of DOI:10.1016/S0957-4166(97)00010-4

The synthesis of (-)-pyrrolam A starting from (R)-prolinol is described. The key step is the dehydrative alkylation of a conveniently protected (R)-prolinol with triethyl methanetricarboxylae under the conditions of the mitsunobu reaction.