Synthesis of UB-165: A novel nicotinic ligand and anatoxin- a/epibatidine hybrid

Article abstract of DOI:10.1016/S0960-894X(97)10090-7

UB-165 (5), a hybrid corresponding to natural anatoxin-a and epibatidine, has been synthesised and shows significant potency at the high affinity nicotine binding site in rat brain Ent-(5) shows a much lower level of activity which parallels the sense of enantiospecificity associated with anatoxin-a.