A novel synthesis of imidazo[2,1-d][1,2,4]triazine and imidazo[2,1- dl]1,2,5]triazepine derivatives via ketene-N,N-acetal

Article abstract of DOI:10.1080/00397919708004107

The ketene-S,S-acetal I was prepared under phase-transfer catalysis (PTC) in benzene-carbonate two phase system using tetrabutylammonium bromide as the catalyst. Upon treatment with 1,2-diaminoethane, followed by hydrolysis with sodium methoxide, I gave 2-(2-oxopropylidene) imidazoline III. Bromination of III and replacement of bromine by hydrazine afforded 2- (1-hydazino-1,2-oxopropylidene) imidazoline V. Compound V was used as a precursor for the preparation of the previously unreported fused nitrogen heterocyclic ring system of imidazotriazine VI, VIII, XI, XII and imidazotriazepine IX, X.

Full text of DOI:10.1080/00397919708004107

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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A Novel Synthesis of
Imidazo[2,1-d][1,2,4]triazine
and Imidazo[2,1-d]
[1,2,5]triazepine Derivatives
via Ketene-N,N-acetal
Ahmed M. M. El-Saghier a , Abdussalam A. Maihub b
& Hatif A. Al-Shirayda b
a Department of Chemistry, Faculty of Science,
Sohag, Egypt
b Department of Pharmaceutical Chemistry, Faculty
of Pharmacy, Al-Arab Medical University, Benghazy,
LIBYA
Published online: 21 Aug 2006.
To cite this article: Ahmed M. M. El-Saghier , Abdussalam A. Maihub & Hatif A. Al-
Shirayda (1997) A Novel Synthesis of Imidazo[2,1-d][1,2,4]triazine and Imidazo[2,1-
d][1,2,5]triazepine Derivatives via Ketene-N,N-acetal, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry, 27:14,
2433-2444, DOI: 10.1080/00397919708004107
To link to this article: http://dx.doi.org/10.1080/00397919708004107
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