Tetrahedron Letters p. 1823 - 1824 (1990)
Update date:2022-08-11
Topics:
Perlman, Kato L.
Sicinski, Rafal R.
Schnoes, Heinrich K.
DeLuca, Hector F.
1α,25-Dihydroxy-19-nor-vitamin D3 has been synthesized via oxidative degradation of the 1α-hydroxycylcovitamin intermediate. Preliminary studies indicate that the new analog induces the differentiation of human leukemia HL-60 cells, with little or no calcemic activity. (Chemical Equation Presented).
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