Palladium-catalyzed cross-coupling of benzyl ketones and α,β- unsaturated carbonyl and phenolic compounds with o-dibromobenzenes to produce cyclic products

Article abstract of DOI:10.1246/bcsj.72.2345

A number of carbonyl and phenolic compounds efficiently couple with o- dibromobenzenes in the presence of a palladium catalyst and a base to give the corresponding oxygen-containing heterocycles or carbocyclic compounds. Thus, from the reactions of benzyl phenyl ketones, 1-naphthols, and α,β- unsaturated aldehydes and ketones, benzofuran, benzopyran, benzocyclobutane, and indene derivatives, respectively, are produced selectively via the successive formation of C-C and C-O bonds or of two C-C bonds.