Synthetic Communications p. 2461 - 2477 (2020)
Update date:2022-08-03
Topics:
Saravanan, Velautham
Rajakumar, Perumal
Triazolophanes with benzophenone and S(-)-BINOL functionalization at the intra annular position have been synthesized by the click reaction of 4,4′-bis(azidomethyl) benzophenone with the corresponding bispropargyloxy compounds. The newly synthesized triazolophanes were characterized by spectral and analytical methods. Triazolophane with S(-)-BINOL and benzophenone functionality at the intra annular position shows good target binding ability in molecular docking studies and also better antibacterial activity against all the four tested pathogens viz. Staphylococcus aureus, Bacillus subtilis, Salmonella typhimurium, and Escherichia coli bacteria.
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