Comparison of aniline hydroxylation by hemoglobin and microsomal cytochrome P450 using stable isotopes

DOI: 10.1016/0378-4274(94)90158-9

Source and publish data:

Toxicology Letters p. 147 - 153 (1994)

Update date:2022-08-25

Topics:

Authors:

Barton, Hugh A.

Marletta, Michael A.

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Article abstract of DOI:10.1016/0378-4274(94)90158-9

Hemoglobin (Hb) and cytochrome P450 carry out aromatic ring hydroxylation of aniline. In the presence of reductants and Hb, para- and ortho-aminophenol were formed. Under [¹⁸O]O₂, 100% of product was labeled: no incorporation occurre

Full text of DOI:10.1016/0378-4274(94)90158-9

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