Bioorganic and Medicinal Chemistry Letters p. 3189 - 3194 (1997)
Update date:2022-08-28
Topics:
Josien, Hubert
David, Bom
Curran, Dennis P.
Zheng, Yu-Huang
Chou, Ting-Chao
The synthesis and biological evaluation of about one dozen 7-silylcamptothecin derivatives are described. Most new compounds show potencies comparable to or better than camptothecin itself. The best compound, 11-fluoro-10-amino-7-trimethylsilylcamptothecin, is more than 20 times more potent than camptothecin in cell assays.
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