7-Silylcamptothecins (silatecans): A new family of camptothecin antitumor agents

DOI: 10.1016/S0960-894X(97)10181-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3189 - 3194 (1997)

Update date:2022-08-28

Topics:

Authors:

Josien, Hubert

David, Bom

Curran, Dennis P.

Zheng, Yu-Huang

Chou, Ting-Chao

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Article abstract of DOI:10.1016/S0960-894X(97)10181-0

The synthesis and biological evaluation of about one dozen 7-silylcamptothecin derivatives are described. Most new compounds show potencies comparable to or better than camptothecin itself. The best compound, 11-fluoro-10-amino-7-trimethylsilylcamptothecin, is more than 20 times more potent than camptothecin in cell assays.

Full text of DOI:10.1016/S0960-894X(97)10181-0

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