Preparation of Enolates from α-Haloketones with n-BuLi, PhMgBr, or Et2Zn via Halogen-Metal Exchange Reaction

Article abstract of DOI:10.1246/cl.1995.463

Metal-halogen exchange of α-iodoketones was performed upon treatment with n-BuLi, PhMgBr, Et2Zn or Me3Al in ether at 0 deg C to give the corresponding metal enolates which reacted with aldehydes to provide the aldol type products in good yields.