Convenient synthesis of trichloromethyldihydroquinolines and -isoquinolines

DOI: 10.1055/s-1994-25578

Source and publish data:

Synthesis p. 800 - 804 (1994)

Update date:2022-08-11

Topics:

Authors:

Grignon-Dubois

Diaba Diaba

Grellier-Marly

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Article abstract of DOI:10.1055/s-1994-25578

The reaction of a series of N-alkylquinolinium and -isoquinolinium iodides towards sodium trichloroacetate in acetonitrile has been investigated under reflux or ultrasonication. In all cases, addition of trichloromethyl anion was observed, and trichloromethyldihydroquinoline or -isoquinoline derivatives were obtained in good yields. Depending on the activation process, addition occurred at the 2- or the 4-position with quinolines and at the 1-position with isoquinolines.

Full text of DOI:10.1055/s-1994-25578

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