Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy p. 80 - 84 (2018)
Update date:2022-08-11
Topics:
Wu, Wei-Na
Wu, Hao
Wang, Yuan
Mao, Xian-Jie
Zhao, Xiao-Lei
Xu, Zhou-Qing
Fan, Yun-Chang
Xu, Zhi-Hong
A coumarin-based sensor C1, namely 3-acetoacetylcoumarin was designed, synthesized and applied for hydrazine detection. Hydrazinolysis of the chemosensor gives a fluorescent coumarin-pyrazole product C1???N2H4 [3-(3-methyl-1H-pyrazol-5-yl)coumarin], and thus resulting in a prominent fluorescence off-on response toward hydrazine under physiological conditions. The probe is highly selective toward hydrazine over cations, anions and other biologically/environmentally abundant analytes. The detection limit of the probe is 3.2?ppb. The sensing mechanism was supported by 1H NMR, IR, MS and DFT calculation. The application of the fluorescent probe in monitoring intracellular hydrazine in glioma cell line U251 was also demonstrated.
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