ACROMELIC ACID C. A NEW TOXIC CONSTITUENT OF CLITOCYBE ACROMELALGA: AN EFFICIENT ISOLATION OF ACROMELIC ACIDS

Article abstract of DOI:10.1016/S0040-4039(00)97501-4

The neurotoxic amino acids, acromelic acids A and B were efficiently isolated from the poisonous mushroom Clitocybe acromelalga, accompanied by a new toxic analogue, acromelic acid C.The structure of acromelic acid C was elucidated to be 1 by comparison of the spectral data with those of acromelic acids A and B.Acromelic acid C exhibited a lethal toxicity of the mice at a dose of 10 mg/kg.