Journal of Organic Chemistry p. 8151 - 8156 (1994)
Update date:2022-08-11
Topics:
Smith, George B.
Dezeny, George C.
Hughes, David L.
King, Anthony O.
Verhoeven, Thomas R.
The key step in the synthesis of the drug substance losartan is a palladium-catalyzed cross-coupling reaction of an aryl bromide and a boronic acid.The reaction scheme was defined in kinetic studies using HPLC, and computer simulation served to depict the
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