Bioorganic and Medicinal Chemistry Letters p. 1683 - 1686 (1998)
Update date:2022-08-29
Topics:
Lee, Koo
Hwang, Sang Yeul
Yun, Mikyung
Kim, Dong Soo
Novel thrombin inhibitors incorporating thienylamidine at the P1 position were designed and synthesized. These compounds are potent, trypsin- selective and efficacious in the rat model of venous thrombosis. The proposed P1 binding mode in the thrombin active site was confirmed by X-ray crystallographic analysis.
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