Marine Drugs p. 668 - 676 (2012)
Update date:2022-08-28
Topics:
Han, Zhuang
Xu, Ying
McConnell, Oliver
Liu, Lingli
Li, Yongxin
Qi, Shuhua
Huang, Xiangzhong
Qian, Peiyuan
Two new antimycin A analogues, antimycin B1 and B2 (1-2), were isolated from a spent broth of a marine-derived bacterium, Streptomyces lusitanus. The structures of 1 and 2 were established on the basis of spectroscopic analyses and chemical methods. The isolated compounds were tested for their anti-bacterial potency. Compound 1 was found to be inactive against the bacteria Bacillus subtilis, Staphyloccocus aureus, and Loktanella hongkongensis. Compound 2 showed antibacterial activities against S. aureus and L. hongkongensis with MIC values of 32.0 and 8.0 μg/mL, respectively.
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