Helvetica Chimica Acta p. 232 - 236 (1987)
Update date:2022-08-10
Topics:
Soukup, Milan
Wipf, Beat
Hochuli, Erich
Leuenberger, Hans G. W.
An enantioselective synthesis of L-threonine (1) is described.Racemic ethyl 2-acetamido-3-oxobutyrate (6) was synthesized from ethyl acetoacetate (2) (4) (5) and then transformed to the epimeric optically active alcohols 7a and 7b by microbiological reduction with Saccharomyces rouxii.The mixture 7a/7b could be converted to 1 by slightly modified, known methods in a yield of ca. 52percent with respect to 7a/7b.
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(1999)
