Frameshift mutagenicity and DNA intercalation of 9-amino-2-hydroxyacridine, a rat liver S9 metabolite of 9-aminoacridine

Article abstract of DOI:10.1271/bbb.60.714

9-Amino-2-hydroxyacridine, a rat liver S9 metabolite of 9-aminoacridine (9-AA), was synthesized, and found to have lower frameshift mutagenicity and stronger DNA binding affinity than 9-AA.

Full text of DOI:10.1271/bbb.60.714

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Frameshift Mutagenicity and DNA Intercalation of 9-
Amino-2-hydroxyacridine, a Rat Liver S9 Metabolite
of 9-Aminoacridine
Hideyuki Tomosakaa, Kentaro Anzaiab, Eietsu Hasegawaac, Tsuneyoshi Horigomea & Saburo
Omataa
a Department of Biosystem Science, Graduate School of Science and Technology, Niigata
University, Igarashi, Niigata, Niigata 950–21, Japan
b Department of Chemistry, Faculty of Science, Science University of Tokyo, Kagurazaka,
Shinuku-ku, Tokyo 162, Japan
c Department of Chemistry, Faculty of Science, Niigata University, Igarashi, Niigata.,
Niigata 950–21, Japan
Published online: 12 Jun 2014.
To cite this article: Hideyuki Tomosaka, Kentaro Anzai, Eietsu Hasegawa, Tsuneyoshi Horigome & Saburo Omata
(1996) Frameshift Mutagenicity and DNA Intercalation of 9-Amino-2-hydroxyacridine, a Rat Liver S9 Metabolite of 9-
Aminoacridine, Bioscience, Biotechnology, and Biochemistry, 60:4, 714-716, DOI: 10.1271/bbb.60.714
To link to this article: http://dx.doi.org/10.1271/bbb.60.714
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