A potent and selective inhibition of parainfluenza 1 (Sendai) virus by new 6-oxiranyl-, 6-methyloxiranyluracils, and 4(3H)-pyrimidinone derivatives

Article abstract of DOI:10.1016/S0960-894X(98)00314-X

Several new 6-oxiranyl-, 6-methyloxiranyluracils, and pyrimidinone derivatives, synthesized by the lithiation-alkylation sequence of 1,3,6- trimethyluracil, 1,3-dimethyl-6-chloromethyluracil, and 2-alkoxy-6-methyl- 4(3H)-pyrimidinones, showed a potent and selective antiviral activity against the parainfluenza 1 (Sendai) virus replication.