Heterocyclic Communications p. 239 - 242 (2003)
Update date:2022-08-11
Topics:
Nyerges, Miklos
Viranyi, Andrea
Toke, Laszlo
A new route to the pyrrolo[3-,4-c]quinoline ring system has been developed. The synthesis proceeds stereoselectively in three steps, using 1,3-dipolar cycloaddition of azomethine ylides as a key step. First, a series of 4-aryl-pyrrolidine-3-carboxylic acid has been prepared from the appropriate cinnamic esters and a non-stabilised azomethine ylide. The reduction of nitro group on the aromatic ring was followed by the acid catalyzed intramolecular lactame formation.
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