Nickel-catalyzed cross-coupling reaction of alkynyl bromides with Grignard reagents

Article abstract of DOI:10.1016/j.cclet.2014.04.019

We describe a convenient method for the synthesis of 1,2-disubstituted acetylenes via a cross-coupling reaction of (bromoethynyl)benzene with Grignard reagents. The reaction of (bromoethynyl)benzene (1 mmol) with Grignard reagent (1.3 mmol) mediated by NiCl₂ (4 mol%) and (p-CH₃Ph)₃P (8 mol%) in THF could produce 1,2-disubstituted acetylenes in good yields at room temperature.