A novel method of indole ring system construction: One-pot synthesis of 4- and 6-nitroindole derivatives via base promoted reaction between 3- nitroaniline and ketones

DOI: 10.1016/S0040-4039(99)01014-X

Source and publish data:

Tetrahedron Letters p. 5395 - 5398 (1999)

Update date:2022-08-28

Topics:

Authors:

Moskalev, Nikolai

Makosza, Mieczyslaw

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Article abstract of DOI:10.1016/S0040-4039(99)01014-X

Base promoted condensation of ketones RCOCH₂R' with 3-nitroaniline results in formation of the corresponding 4- and 6-nitro-2-R-3-R'-indoles. This multistep process apparently includes oxidative nucleophilic substitution of hydrogen in the arom

Full text of DOI:10.1016/S0040-4039(99)01014-X

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