Synthesis and characterization of phosphonic acid-substituted amino acids as excitatory amino acid receptor antagonists

Article abstract of DOI:10.1080/10426509608545152

Decahydroisoquitioline-3-carboxylic acids, substituted at C-6 with an acidic moiety such as a phosphonic, sulfonic or carboxylic acid or tetrazole, were prepared as antagonists of excitatory amino acid (EAA) receptors.

Full text of DOI:10.1080/10426509608545152

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Phosphorus, Sulfur, and Silicon and
the Related Elements
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Synthesis and Characterization
of Phosphonic Acid-Substituted
Amino Acids as Excitatory Amino
Acid Receptor Antagonists
Paul L. Ornstein , M. Brian Arnold , Nancy K. Allen &
Darryle D. Schoepp
a Central Nervous System Research Division, Lilly Research
Laboratories, A Division of Eli Lilly and Company, Lilly
Corporate Center , Indianapolis, Indiana, 46285, USA
b Central Nervous System Research Division, Lilly Research
Laboratories, A Division of Eli Lilly and Company, Lilly
Corporate Center , Indianapolis, Indiana, 46285, USA
c Central Nervous System Research Division, Lilly Research
Laboratories, A Division of Eli Lilly and Company, Lilly
Corporate Center , Indianapolis, Indiana, 46285, USA
d Central Nervous System Research Division, Lilly Research
Laboratories, A Division of Eli Lilly and Company, Lilly
Corporate Center , Indianapolis, Indiana, 46285, USA
Published online: 06 Aug 2008.
To cite this article: Paul L. Ornstein , M. Brian Arnold , Nancy K. Allen & Darryle D. Schoepp
(1996) Synthesis and Characterization of Phosphonic Acid-Substituted Amino Acids as
Excitatory Amino Acid Receptor Antagonists, Phosphorus, Sulfur, and Silicon and the Related
Elements, 109:1-4, 309-312
To link to this article: http://dx.doi.org/10.1080/10426509608545152
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